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KMID : 0964020100100010055
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Journal of the Korean Liver Cancer Study Group
2010 Volume.10 No. 1 p.55 ~ p.60
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Two Cases of Hepatocellular Carcinoma with Extrahepatic Metastasis Who Showed Complete Remission Following Doxorubicin and Cisplatin (AP) Combination Chemotherapy in Reduced Dosage
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Nam Seung-Bum
Han Chul-Ju
Lee Ho-Jin
Kim Youn-Joo
Yang Gi-Young
Park Su-Cheol
Kim Jin
Kim You-Cheoul
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Abstract
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The effect of systemic chemotherapy in patients with advanced HCC is very limited, not only in regard to poor response
to cytotoxic chemotherapeutic agents but also poor tolerance to therapy and related adverse effects. Herein, we report two
cases of hepatocellular carcinoma (HCC) with extrahepatic metastasis who achieved complete remission following
administration of doxorubicin and cisplatin in reduced dosage. The first case was a 41-year-old male who had HCC with
multiple lung and intraabdominal lymph nodes metastasis. After 9 cycles of chemotherapy with 50% reduced dosage, he
achieved a complete remission of both primary and metastatic lesions. He showed no evidence of disease for 11 more months during follow-up and still lives without recurrence. The second case was a 61-year-old female who had HCC with inferior vena cava thrombosis and multiple lung metastasis. After one cycle of treatment with 25% reduced dosage, she underwent life-threatening toxicities and poor tolerance to chemotherapy and further treatment was discontinued. However, she achieved a complete remission of both primary and metastatic lesions. Following 26 months of recurrence free period, she suffered from a recurrent tumor near previously treated lesion, which was successfully treated by TACE and radiation therapy. This modified doxorubicin and cisplatin regimen in reduced dosage could be used as means of evading life threatening toxicity and selecting out responders to systemic chemotherapy with reduced risk.
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KEYWORD
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Hepatocellular carcinoma, Chemotherapy, Doxorubicin, Cisplatin, Reduced dosage
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